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Prometrium Soft Gel | Progesterone Capsules

Prometrium Soft Gel | Progesterone Capsules

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PROMETRIUM Capsules are used for the prevention of endometrial hyperplasia which is caused by excess estrogen without progesterone. If ovulation does not occur, progesterone is not made, and the lining is not shed. The endometrium may continue to grow in response to estrogen. The cells that make up the lining may crowd together and may become abnormal in non-hysterectomized in which uterus and cervix are not removed, in postmenopausal women who are receiving estrogens tablets. They are also indicated for use in secondary amenorrhea which is define as the absence of menstrual bleeding in a woman who had been menstruating but later stops menstruating for three or more months in the absence of pregnancy, lactation (production of breast milk), cycle suppression with systemic hormonal contraceptive (birth control) pills, or menopause.

Progesterone is a female hormone responsible for ovulation and menstruation. Progesterone causes changes in the lining of the uterus and making easier for a fertilized egg to attach to the uterus at the beginning of pregnancy. Progesterone helps body to maintain the pregnancy.

Progesterone is also indicated, to prevent abnormal growth and cancer of the uterus. Do not take progesterone if you have breast cancer.

Dose and Administration:

For Endometrial Hyperplasia

-          Take one capsule daily in the evening, 200 mg orally for 12 days sequentially per 28 day cycle, to postmenopausal women who are receiving daily conjugated estrogens tablets.

For Secondary Amenorrhea

-          Administer one capsule daily, having dose of 400 mg in evening for 10 days.

Side - Effects:

-          Abdominal Pain.

-          Breast Pain.

-          Joint Pain.

-          Vaginal discharge.

-          Chest Pain.


-          Patients with known or suspected pregnancy, liver diseases, cancer of breast, undiagnosed vaginal bleeding and missed abortion.


-          Ketoconazole.

-          Aspirin.

-          Aminophylline.

-          Carbamazepine.

-          Indinavir.


-          Peanut.

-          Grapefruit.


-          Not recommended.


-          Store at 25 degree Celsius, dispense in tight container and prevent from moisture.

Patient Education:

-          This capsule contains peanut oil and should not be used if you are allergic to peanuts.

-          Avoid driving a motor vehicle or operating machinery as  this capsule may cause dizziness or drowsiness.

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